Effect of colchicine on the immunohistochemical localization of somatostatin in the rat brain: light and electron microscopic studies.
Open Access
- 1 December 1979
- journal article
- research article
- Published by SAGE Publications in Journal of Histochemistry & Cytochemistry
- Vol. 27 (12) , 1577-1581
- https://doi.org/10.1177/27.12.391994
Abstract
Somatostatin (SRIF), the hypothalmic hormone which inhibits the secretion of growth hormone by the pituitary, has been localized immunohistochemically in the rat hypothalamus after intracerebral injection of colchicine. The number of cell bodies staining for SRIF was increased in the periventricular nucleus while the number of nerve fibers was decreased in the median eminence after treatment. The number of secretory granules containing SRIF in the nerve cell bodies was increased in the treated animals, suggesting a correlation between the number of specific secretory granules and intensity of the immunohistochemical reaction. These observations are in agreement with the hypothesis that SRIF cell bodies in the periventricular nucleus send their axons into the median eminence.This publication has 1 reference indexed in Scilit:
- Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.Proceedings of the National Academy of Sciences, 1977