Abstract
Although there are many reports of female anorgasmia as a side effect of tricyclic antidepressants, less has been written in regard to hypoactive sexual desire disorder. A case is presented of a 44-year-old woman who developed hypoactive sexual desire (sexual indifference) when placed on Doxepin. After her prescription was changed to Nortriptyline, her sexual desire returned. This change in sexual desire may have been due to Doxepin being more anticholinergic, considerably more serotonergic, or slightly less adrenergic than Nortriptyline.

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