The Treatment of Syphilis with Antibiotics Other Than Penicillin

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Abstract
Shortly after Mahoney's1 original observation that penicillin was effective in the treatment of human syphilis, it was known that penicillin produced allergic reactions in some persons. Subsequently, reports in the literature indicated that such reactions might be expected in from 1% to 6% of treated patients. With growing frequency, the physician faced the problem of choosing a therapeutic agent for patients with syphilis who were sensitive to penicillin. The choice was either a return to the difficulties and dangers of treatment with arsenic and bismuth or the utilization of some other antibiotic with treponemicidal properties. The latter choice presented a problem to the average physician of accumulating and evaluating occasional and widely scattered reports in the literature. It is the purpose of this paper to review the literature and to select and comment upon some of the possible choices available to the physician

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