Asymmetric Desymmetrisation of Meso-Norbornene Anhydrides Utilising Methyl Prolinate as a Chiral Reagent
- 1 June 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (06) , 639-640
- https://doi.org/10.1055/s-1995-5023
Abstract
The reaction between methyl S-prolinate and meso-norbornene derived anhydrides was found to give amido-acids with excellent asymmetric induction. This methodology provides an inexpensive route for the preparation of optically pure, polycyclic, highly functionalised starting materials for natural and unnatural product synthesis on a large scale.Keywords
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