GROWTH HORMONE AND CARDIAC GLYCOGEN: INFLUENCE OF ENVIRONMENTAL AND GENETIC FACTORS

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Abstract
The rise in cardiac glycogen levels observed in the rat during fasting and after growth hormone administration is more difficult to demonstrate in the mouse. At room temperature fasting lowers the cardiac glycogen of the mouse. Large doses of growth hormone are needed to maintain the cardiac glycogen at the level seen in fed animals. At 30 °C mice of the A strain increase their cardiac glycogen during a 24-hour fast. Growth hormone increases the glycogen level still further. At this elevated temperature (close to the critical temperature of the mouse) fasting lowers the cardiac glycogen of the I strain mouse, but growth hormone raises the glycogen above the level of fed animals. It is suggested that the fasting stimulus evokes a greater secretion of growth hormone in A strain mice or that the tissues of these mice are more sensitive to the hormone.