INTRACELLULAR VIRUS CRYSTALS IN THE CENTRAL NERVOUS SYSTEM OF MICE FOLLOWING RODENT POLIOENCEPHALITIS (MM STRAIN) INFECTION

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Abstract
Mice were injected subcutaneously with 0.5 ml of a 10-4 suspension of brain homogenate infected with MM strain of the Columbia SK group of rodent polioencephalitis virus. Paralysis and necrotizing polioencephalitis were seen in animals sacrificed 3 days after infection. In a cell tentatively identified as a neuron, there were intracytoplasmic aggregations of particles of varying density which measured 18-20 micra and are believed to represent intracellular virus multiplication in the living animal. Homogenates of brain from this animal were 100% pathogenic for further mouse passages.