Release of Calcitonin Gene—Related Peptide from Sensory Neuronsa
- 1 June 1992
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 657 (1) , 187-193
- https://doi.org/10.1111/j.1749-6632.1992.tb22767.x
Abstract
CGRP is released from capsaicin-sensitive sensory neurons in a Ca(2+)-dependent manner in a variety of peripheral organs as well as from central terminals. The mechanisms for CGRP release by low concentrations of capsaicin, electrical antidromic nerve stimulation, and bradykinin have several similar characteristics regarding sensitivity to TTX, CTX, and alpha 2-adrenoceptor activation. High capsaicin concentration and nicotine evoke CGRP release via other mechanisms. The effects of capsaicin, resiniferatoxin, and SO2 are blocked by RR, which probably inhibits ion fluxes associated with capsaicin receptor activation. CGRP released upon irritation of peripheral branches of primary afferents may evoke a variety of cardiovascular actions and influence motility in the gastrointestinal and urogenital tracts.Keywords
This publication has 42 references indexed in Scilit:
- Different ion channel mechanisms between low concentrations of capsaicin and high concentrations of capsaicin and nicotine regarding peptide release from pulmonary afferentsActa Physiologica Scandinavica, 1992
- Selective inhibition by dactinomycin of NANC sensory bronchoconstriction and [125I] NKA binding due to NK‐2 receptor antagonismActa Physiologica Scandinavica, 1992
- Sulfur Dioxide-Induced Bronchoconstriction via Ruthenium Red-Sensitive Activation of Sensory NervesRespiration, 1992
- Selectivity of ruthenium red in inhibiting bronchoconstriction and CGRP release induced by afferent C‐fibre activation in the guinea‐pig lungActa Physiologica Scandinavica, 1991
- Omega‐conotoxin inhibits CGRP release and bronchoconstriction evoked by a low concentration of capsaicinActa Physiologica Scandinavica, 1991
- Sensory neuron-specific actions of capsaicin: mechanisms and applicationsTrends in Pharmacological Sciences, 1990
- Ruthenium red selectively inhibits capsaicin-induced release of calcitonin gene-related peptide from the isolated perfused guinea pig lungNeuroscience Letters, 1989
- Lschaemia and changes in contractility induce release of calcitonin gene‐related peptide but not neuropeptide Y from the isolated perfused guineapig heartActa Physiologica Scandinavica, 1987
- Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the ratNeuroscience Letters, 1984
- Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processingNature, 1983