Nisamycin, a new manumycin group antibiotic from Streptomyces sp. K106. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
- 1 January 1994
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 47 (10) , 1104-1109
- https://doi.org/10.7164/antibiotics.47.1104
Abstract
Nisamycin, a new manumycin group antibiotic, was isolated from the culture broth of Streptomyces sp. K106. This strain was designated to genus Streptomyces by the taxonomic features. Nisamycin was purified by ethyl acetate extraction, silica gel column chromatography, preparative silica gel TLC, and Sephadex LH-20 column chromatography as a pale yellow powder. Nisamycin is active against Gram-positive bacteria and fungi, and exhibits a cytotoxic activity.Keywords
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