Distinctive Effects of CCR5, CCR2, and SDF1 Genetic Polymorphisms in AIDS Progression
Open Access
- 1 December 1998
- journal article
- research article
- Published by Wolters Kluwer Health in JAIDS Journal of Acquired Immune Deficiency Syndromes
- Vol. 19 (4) , 381-386
- https://doi.org/10.1097/00042560-199812010-00009
Abstract
The Genetics of Resistance to Infection by HIV-1 (GRIV) cohort represents 200 nonprogressor/slow-progressor (Slowprog) and 90 fast-progressor (Fastprog) HIV-1-infected patients. Using this unique assembly, we performed genetic studies on three recently discovered polymorphisms of CCR5, CCR2, and SDFI, which have been shown to slow the rate of disease progression. The increased prevalence of mutant alleles among Slowprogs from the GRIV cohort was significant for CCR5 (p CCR2 (pKeywords
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