Conditions of hypertrophy of seminal vesicles in rats

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Abstract
Sex hormones are specific not for whole organs but only for certain tissues, independently of the sex of the individual. In sex organs estrogenic substances promote growth of smooth muscle, stratified epithelium and some glandular epithelia of ectodermal origin, the latter when not located in tubes like uterus or seminal vesicles. The development of glandular epithelium to its secretory stage is subject either to [male] or to corpus luteum hormone, while these also counteract noxious effects of estrin derivatives on these structures. In [female] rats and rabbits 100-1000 M.U. of estrin daily during several weeks induce a submucous "fibroid" and infiltration with eosinophilic leucocytes. In [male][male] some parts of excretory duct epithelia of prostate and seminal vesicles are metaplasic after treatment with estrogenic compounds, showing cornifying stratified, instead of columnar type, while the muscular walls of the seminal vesicles strongly hypertrophy and eosinophilic infiltration occurs. The myotropic effect of the following crystalline substances was investigated on seminal vesicles of infantile castrated rats and roughly compared with the estrogenic potency: Oestrone, Oestriol, Equilenin, Equilin, reduced Equilin, Oestradiol, monobenzoate, dibenzoate and diacetate of Oestradiol, benzoate and acetate of Oestrone, monomethyl ether of Oestradiol. The myotropic effect is associated with the estrogenic one, but by comparing min. active doses the myotropic effect is comparatively enhanced in Oestradiol, its monobenzoate and diacetate, and in reduced Equilin with reference to earlier known estrogenic substances. This phenomenon, however, could not be consistently ascribed to any of the known structural properties of the estrin derivatives.

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