Properties of developmental gene regulatory networks
- 23 December 2008
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 105 (51) , 20063-20066
- https://doi.org/10.1073/pnas.0806007105
Abstract
The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits controlling the specification of the mesectoderm in the Drosophila embryo and the endomesoderm in the sea urchin, even though the respective subcircuits are composed of nonorthologous regulatory genes.Keywords
This publication has 26 references indexed in Scilit:
- How the Dorsal gradient works: Insights from postgenome technologiesProceedings of the National Academy of Sciences, 2008
- Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryoProceedings of the National Academy of Sciences, 2008
- The Caenorhabditis elegans vulva: A post-embryonic gene regulatory network controlling organogenesisProceedings of the National Academy of Sciences, 2008
- A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2Proceedings of the National Academy of Sciences, 2008
- Synteny and candidate gene prediction using an anchored linkage map of Astyanax mexicanusProceedings of the National Academy of Sciences, 2008
- Regulatory logic of neuronal diversity: Terminal selector genes and selector motifsProceedings of the National Academy of Sciences, 2008
- Characterization of the Drosophila segment determination morphomeDevelopmental Biology, 2007
- A missing link in the sea urchin embryo gene regulatory network: hesC and the double-negative specification of micromeresProceedings of the National Academy of Sciences, 2007
- Cis-regulatory control of the nodal gene, initiator of the sea urchin oral ectoderm gene networkDevelopmental Biology, 2007
- Dorsal-Ventral Pattern of Delta Trafficking Is Established by a Snail-Tom-Neuralized PathwayDevelopmental Cell, 2006