Effect of X-Irradiation on Connective Tissue Ground Substance

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Abstract
Comparison was made of the size of connective tissue bullae in normal and X-irradiated mice after injns. with isosmotic sucrose, hypertonic sucrose, and histamine solns. In one expt. the bullae were measured at 1,4 1/2, and 8 min. after injn.; in another at 8, 36, and 162 min. Mice were irradiated over the whole body with 500 r (210 kv) approx. 24 hrs. before injn. The results are interpreted as follows: (1) Previous X-irradiation causes a more rapid breakdown of bullae produced by subcut. injn. This is not a result merely of an increase in rate of normal breakdown processes. (2) Previous X-irradiation decreases the size of bulla produced on injn. by decreasing the amt. of mucopolysaccharide available. (3) Histamine stimulates the formation of mucopolysaccharide in the ground substance. It is concluded that the dose of X-rays used did not inhibit mucopolysaccharide formation. (4) The ground substance acts as a differentially permeable membrane to hypertonic sucrose solns. so that bullae formed by such solns. take up water either from the blood stream, the intercellular space or from both. (5) Capillary permeability is conditioned by the permeability of the investing ground substance. (6) Under the exptl. conditions, neither histamine nor hypertonic sucrose increased the permeability of the capillaries. X-irradiation increased capillary permeability through its effect on the ground substance.

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