DOG-RESPONSE TO INACTIVATED CANINE PARVOVIRUS AND FELINE PANLEUKOPENIA VIRUS-VACCINES

  • 1 January 1982
    • journal article
    • research article
    • Vol. 72  (1) , 16-35
Abstract
Inactivated canine parvovirus (CPV) and inactivated feline panleukopenia virus (FPV) vaccines were evaluated in dogs. Maximal serologic response occurred within 1-2 wk after vaccination. Antibody titers then declined rapidly to low levels that persisted at least 20 wk. Immunity to CPV, defined as complete resistance to infection, was correlated with serum antibody titer and did not persist longer than 6 wk after vaccination with inactivated virus. Protection against generalized infection was demonstrated 20 wk after vaccination. In unvaccinated dogs, viremia and generalized infection occurred after oronasal challenge with virulent CPV. Viral replication was restricted to the intestinal tract and gut-associated lymphoid tissue of vaccinated dogs. Canine parvovirus was inactivated by formalin, .beta.-propiolactone (BPL) and binary ethylenimine (BEI) in serum-free media; inactivation kinetics were determined. Formalin resulted in a greater loss of viral HA than either BEI or BPL, and antigenicity was correspondingly reduced.

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