The Electrical Properties of Cell Membranes in Granular or Agranular Anterior Pituitary Clonal Cells
- 1 March 1979
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 160 (3) , 291-295
- https://doi.org/10.3181/00379727-160-40437
Abstract
Summary The electrical properties of the membrane of granular and agranular growth hormone-secreting clonal cells derived from the same parent clone of rat anterior pituitary cells were studied by the intracellular micro-electrode technique. An evoked spike potential was generated by a depolarizing current in the granular (SR7E8) but not in the agranular (SR7F2) clonal cells. The potential was not suppressed by tetrodotoxin (TTX), but could be abolished by somatostatin, verapamil and D-600. It, therefore, seems likely that it is a Ca-potential, rather than a Na-potential.This publication has 7 references indexed in Scilit:
- Accumulation of secretory granules in pituitary clonal cells derived from the epithelium of Rathke's pouchCell and tissue research, 1978
- Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell lineNature, 1977
- Somatostatin: Its inhibiting effect on the release of hormones and IgG from clonal cells strains its Ca-influx dependenceBiochemical and Biophysical Research Communications, 1977
- Action potentials in the rat chromaffin cell and effects of acetylcholine.The Journal of Physiology, 1976
- Electrical excitability of cultured adrenal chromaffin cells.The Journal of Physiology, 1976
- Radioimmunoassayable Growth Hormone in the Rat Pituitary Gland: Effects of Age, Sex and Hormonal StateEndocrinology, 1967
- Stimulation of Release of Follicle-Stimulating Hormone by Hypothalamic Extractsin Vitroandin VivoEndocrinology, 1965