Abstract
Recently there have been descriptions of distinctive neuropathologic features of MSA consisting of oligodendroglial 6–11 and neuronal 12–14 intracytoplasmic and intranuclear argyrophilic inclusions containing accumulations of tubular structures. The glial cytoplasmic inclusions (GCIs) are present in all MSA brains, regardless of whether the patients were diagnosed in life as having SND, SDS, or sOPCA-type MSA. 6,14,15 In contrast, GCIs were not initially 6 found in a large number of neurologic controls, including patients with Parkinson's disease, progressive supranuclear palsy (PSP), and Machado-Joseph disease. However, a recent report 16 indicates that, although characteristic of MSA, the presence of GCIs is not …

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