Rise in Serum Immunoreactive Glucagon After Intrajejunal Glucose in Pancreatectomized Dogs.

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Abstract
Summary Immunoreactive glucagon was detected in the pancreas and the small and large intestines of 4 different animals. Immunological differences existed between pancreatic and jejunal glucagon in the human and dog, but pancreatic and rectal glucagon appeared similar. A rise in serum immuno-reactive glucagon was demonstrated in unanaesthetized dogs after oral glucose. Basal serum glucagon levels in dogs fell only slightly after pancreatectomy. A marked rise in serum immunoreactive glucagon occurred after intrajejunal glucose in pancreatectomized dogs, suggesting its enteric source. An insulinogenic role for intestinal glucagon is considered.

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