LIMITED CLEAVAGE OF HUMAN IMMUNOGLOBULINS BY ELASTASE OF HUMAN NEUTROPHIL POLYMORPHONUCLEAR GRANULOCYTES - POSSIBLE MODULATOR OF IMMUNE-COMPLEX DISEASE
- 1 January 1978
- journal article
- research article
- Vol. 39 (4) , 313-321
Abstract
Human polymorphonuclear lysosomal granules contain a neutral protease which is capable of digesting human immunoglobulins [Ig]. The protease is located in the azurophil granules and enzymatically cleaves IgG, producing a Fab-like piece which is recoverable. The Fc-like fragment is not crystallized. The Fab-like fragment competes effectively for ligands formed by native antibody from which the fragments were produced.This publication has 3 references indexed in Scilit:
- Localization of Chymotrypsin-Like Cationic Protein, Collagenase and Elastase in Azurophil Granules of Human Neutrophilic Polymorphonuclear LeukocytesHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1977
- Subcellular Distribution of Human Leukocytic CathepsinsBlood, 1968
- Proteases of Human LeukocytesBlood, 1960