Reduction by thiopental of the slow-channel-mediated action potential of canine papillary muscle
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 372 (3) , 285-286
- https://doi.org/10.1007/bf01063865
Abstract
The negative inotropic effect of thiopental was examined on the canine papillary muscle. The slow-channel-mediated action potential was induced by 5mM of caffeine in high-K (27 mM) Tyrode solution. The drug reduced the slow action potential and the twitch tension, suggesting a reduction in the slow inward current.Keywords
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