The Effect of the Administration of Sodium Bicarbonate and of Ammonium Chloride on the Amount of Ascorbic Acid Found in the Urine

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Abstract
Ium chloride, in amounts sufficient to induce marked changes in the hydrogen ion concentration of the urine, on the excretion of ascorbic acid has been studied in two normal young adults under controlled conditions of vitamin C depletion and saturation. The ascorbic acid content of the urine was consistently and significantly lower during periods of sodium bicarbonate administration, when the urine was highly alkaline, as compared with similar periods of ammonium chloride administration with a highly acid urine.