Experimental studies of the potentiation of proguanil and pyrimethamine by dapsone usingPlasmodium bergheiin white mice
- 1 June 1977
- journal article
- research article
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 71 (2) , 131-139
- https://doi.org/10.1080/00034983.1977.11687171
Abstract
An accurate system with stringent criteria was established to test antimalarial drugs and drug combinations against P. berghei in mice. Minimum effective doses for a number of antimalarial drugs were determined when used in this system. Considerable potentiation of the activity of pyrimethamine and to a somewhat less extent of proguanil by dapsone was demonstrated. The need to extend studies of these combinations to the parasites of human malaria is discussed in terms of establishing a safe chemoprophylactic regime in the presence of drug-resistant strains of parasites.This publication has 18 references indexed in Scilit:
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