Effects of Experimental Coarctation of the Aorta on the Blood Pressure of Sheep

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Abstract
Blood pressures have been taken from the carotid and femoral artery in sheep following experimental coarctation of the aorta at about the level of the ligamentum arteriosum. Systolic, diastolic, mean, and pulse pressures have been recorded at intervals of from 3 to 6 months over a period of as long as 3 years in some cases. Unoperated sheep have been used as controls. The main changes are a rise in all the carotid pressures and in the femoral diastolic, a fall in the femoral systolic and pulse pressures, and no significant change in the femoral mean pressure. These changes in hemodynamics resulting from coarctation may be adequately explained by the mechanical effects of the coarctation. Over a period of 3 years there is a slight rise of blood pressures in both the normal and the coarctated sheep.

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