The Clinical and Genetic Spectrum of the Holt-Oram Syndrome (Heart-Hand Syndrome)
Open Access
- 31 March 1994
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 330 (13) , 885-891
- https://doi.org/10.1056/nejm199403313301302
Abstract
The Holt-Oram syndrome is an autosomal dominant condition characterized by skeletal abnormalities that are frequently accompanied by congenital cardiac defects. The cause of these disparate clinical features is unknown. To identify the chromosomal location of the Holt-Oram syndrome gene, we performed clinical and genetic studies.Keywords
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