EFFECT OF HEMOPHILUS-SOMNUS ON BOVINE ENDOTHELIAL-CELLS IN ORGAN-CULTURE
- 1 January 1981
- journal article
- research article
- Vol. 42 (5) , 748-754
Abstract
The effect of 2 strains of H. somnus on bovine endothelial cells in cultured arterial segments was investigated and compared with the effects of Escherichia coli and Salmonella typhimurium. In cultures inoculated with either strain of H. somnus, there was widespread contraction and desquamation of endothelial cells, exposing large areas of subendothelial collagen. Many bacteria were adherent to endothelial cells and some were in phagosomes within cells. Endothelial changes were milder in arterial cultures inoculated with E. coli or S. typhimurium than in those inoculated with either strain of H. somnus. Adhesion of H. somnus to vascular endothelial cells followed by exposure of subendothelial collagen may initiate the thrombosis, vasculitis and ischemic necrosis characteristic of infectious thromboembolic meningoencephalitis in cattle. Arterial cultures might be useful in assaying the virulences of different strains of H. somnus and could be used to investigate the mechanism of their action on endothelial cells.This publication has 4 references indexed in Scilit:
- SEPTICEMIA AND MENINGOENCEPHALITIS IN PASTURED CATTLE CAUSED BY A HAEMOPHILUS-LIKE ORGANISM (HEMOPHILUS SOMNUS)1977
- CELLULAR MIGRATION AND REPLICATION IN ENDOTHELIAL REGENERATION - STUDY USING IRRADIATED ENDOTHELIAL CULTURES1977
- BOVINE ABORTION ASSOCIATED WITH HAEMOPHILUS-SOMNUS1975
- INFECTIOUS THROMBOEMBOLIC MENINGOENCEPHALOMYELITIS (SLEEPER SYNDROME) IN FEEDLOT CATTLE1966