Comparative Blanching Activities of Proprietary Diflucortolone Valerate Topical Preparations

Publisher Website
Google Scholar
Abstract
The blanching activities and hence bioavailabilities of the cream, ointment and fatty ointment preparations of Nerisone® and Temetex® (diflucortolone valerate 0.1%) were evaluated using an occluded and unoccluded blanching assay. These products were compared to Synalar® ointment and cream (fluocinolone acetonide 0.025%), established topical corticosteroid preparations. Statistical analysis showed no significant differences between similar formulations of diflucortolone valerate. Significant differences were noted between diflucortolone valerate and fluocinolone acetonide preparations.