Platelet-activating factor stimulates the release of atrial natriuretic factor from the rat heart
- 1 August 1991
- journal article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 130 (2) , 281-288
- https://doi.org/10.1677/joe.0.1300281
Abstract
Atrial natriuretic factor (α-ANF(99–126); ANF) is released from atrial cells following atrial distension, myocardial infarction and periods of ischaemic or tachyarrhythmias. In this report we demonstrate that platelet-activating factor (PAF) stimulates ANF release from the isolated perfused rat heart and following i.v. injection to conscious unrestrained rats. ANF release peaked at 145% above baseline following injection of 2·5 nmol PAF into the isolated heart while administration of 2 nmol in vivo produced a 135% increase in plasma ANF levels. The PAF receptor antagonist BN52021 (10 μmol/l) attenuated this stimulated release, with the results suggesting a role for PAF in ANF secretion following release from damaged myocardium or as a humoral factor originating from the kidney. Journal of Endocrinology (1991) 130, 281–288Keywords
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