Red cell sensitization due to anti‐D in anti‐lymphocyte globulin

Abstract
Four Rh‐positive patients with severe aplastic anemia received equine anti‐lymphocyte globulin. Each developed a positive direct antiglobulin test. Anti‐D was identified in eluates prepared from the patients' sensitized red cells. The administered lot of anti‐lymphocyte globulin was found to contain anti‐D. Red cell sensitization due to passively acquired Rh antibodies can result from the administration of anti‐lymphocyte globulin.