A 2‐Year Study of Adjunctive Minocycline‐HCl in Actinobacillus actinomycetemcomitans‐Associated Periodontitis

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Abstract
To study the effects of a step‐wise treatment regimen on Actinobacillus actinomycetemcomitans‐(Aa) associated periodontitis, 4 clusters among 33 patients harboring the organism were followed during successive periods of systemic minocycline plus mechanical debridement and minocycline plus modified Widman flap treatment. Localized Periodontitis was found in 2 clusters, one with 7 localized juvenile periodontitis patients and a 24‐year old male with localized destruction and extremely low plaque levels (UP), and the other consisting of 10 patients with plaque and gingivitis and a wider age range (16 to 54 years, LP). Generalized severe and moderate periodontitis was found in 2 clusters which were further discriminated by severe gingivitis and high levels of supragingival plaque (9 patients, GSP), and mild inflammation and low plaque levels (6 patients, GMP). Mean percentages of Aa, as determined by selective cultivation of microbiota from at least 2 periodontal pockets of 6 mm or more were 63, 16, 33, and 7.8% in the clusters (P P Aa Periodontitis, but inappropriate in more severe and generalized forms to predictably eliminate Aa. Controlled long‐term studies with larger groups of patients will be needed to establish the difference in treatment response suggested by these studies. J Periodontol 1993; 64:509–519.