THE ROLE OF THYROID GLAND AND OESTROGEN IN THE REGULATION OF GONADOTROPHIC ACTIVITY OF THE ANTERIOR PITUITARY

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Abstract
It has been generally accepted that the secretion of gonadotrophic substances by the pituitary may be inhibited by sex hormones. This specific action of sex hormone on the pituitary is not supposed to be related to the functional state of other glands. Recently, Chu & Lee [1942] called attention to the fact that complete thyroidectomy in the rabbit causes hypertrophy of follicles, but prevents ovulation occurring after coitus. They also produced evidence to show that the failure of ovulation in the thyroidectomized rabbits is not due to the loss of sensitivity of the ovary nor is it due to inhibition of the reflex initiated by coitus. They believe that the formation of the ovulating hormone may be prevented by extirpation of the thyroid. On the other hand, the follicular hypertrophy is an indication of increased secretion of folliclestimulating hormone by the pituitary. If we assume that the pituitary of thyroidectomized

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