Induction of Cell-Mediated Immunity Against Leukemia EL4 in C57BL Mice2

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Abstract
The subcutaneous growth of leukemia EL4 in C57BL mice was suppressed when the tumor cells were mixed with immune BALBjc anti-EL4 peritoneal exudate lymphoid cells before injection into C57BL mice. The protected mice showed increased resistance to a subsequent subcutaneous or intraperitoneal challenge with EL4 tumor cells alone. Effector cells of C57BL origin and cytotoxic for EL4 tumor cells in vitro were detected in the peritoneal cell exudate and also prevented subcutaneous EL4 tumor growth in C57BL mice. These experiments demonstrated a means for the induction of cellular immunity against a lethal tumor in susceptible hosts.