Electrophysiological actions of Mexiletine (Köl 173) on canine Purkinje fibres and ventricular muscle

  • 1 September 1979
    • journal article
    • Vol. 67  (1) , 143-152
Abstract
1 The effects of mexiletine (Kö1173) were investigated in canine isolated cardiac Purkinje fibres and ventricular muscle with microelectrodes. Some Purkinje fibres were depolarized by mechanical stretch to induce spontaneous activity with slow upstroke velocity. The preparations were stimulated at rates of 1, 2, 3 and 4 Hz. The drug concentrations tested were 0.4, 2 and 10 μg/ml in Tyrode solution (KCl = 5.4 mM).