The Synthesis of Substituted Methoxy-Poly(Ethyleneglycol) Derivatives Suitable for Selective Protein Modification
- 1 August 1992
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 22 (16) , 2417-2424
- https://doi.org/10.1080/00397919208019100
Abstract
The syntheses of methoxypoly(ethyleneglycol) derivatives, functionalized either as hydrazides for the selective attachment of methoxypoly(ethyleneglycol) to carbohydrate domains of glycoproteins, or as iodoacetamides and maleimides for the modification of free sulfhydryl groups, are described.Keywords
This publication has 3 references indexed in Scilit:
- A new procedure for the synthesis of polyethylene glycol-protein adducts; Effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and α2-macroglobulinAnalytical Biochemistry, 1983
- Attachment of drugs to polyethylene glycolsEuropean Polymer Journal, 1983
- Irreversible coupling of immunoglobulin fragments to preformed vesicles. An improved method for liposome targeting.Journal of Biological Chemistry, 1982