Facilitated Recovery of Cardiac Performance by Triiodothyronine following a Transient Ischemic Insult

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Abstract
Reperfusion following a transient ischemic insult has been shown to result in a delayed recovery of myocardial function. A reduction in plasma triiodothyronine (T3) has been reported in these acute cardiovascular challenges. To test whether the replacement of T3 can facilitate the recovery of myocardial function following a transient regional ischemia, we investigated cardiac performance for 3 h after a 15-min, left anterior descending coronary artery occlusion in a canine model. Three groups of dogs were studied: I – control (n = 10); II -receiving T3 (0.25 µg/kg i.v. and 0.25 µg/kg/h for 3 h, n = 9), and III – receiving T3 (0.25 µg/kg i.v. and 0.5 µg/kg/h for 3 h, n = 9). Three hours following reperfusion, the T3 level in blood was significantly decreased in group I. Concomitantly, local segmental shortening was reduced from preocclusion control levels in group I (15.2 to 5.1%, p 3 facilitates recovery of the stunned myocardium by improvement in local and global contractile function, in ventriculoarterial coupling, and in the energy efficiency.

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