Critical cation balance in B → Z transition: role of Li+
- 28 November 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 164 (1) , 33-37
- https://doi.org/10.1016/0014-5793(83)80013-1
Abstract
The sodium salt of poly(dGdC) is known to exhibit a B → Z transition in the presence of various cations and 60% alcohol. We here show that the lithium salt of poly(dGdC) does not undergo B → Z transition in the presence of 60% alcohol since Li + with its large hydration shell cannot stabilize the Z-form. On the other hand, high concentrations of Mg 2+ or micromolar concentrations of the cobalt hexamine complex which are known to stabilize the Z-form can compete with Li + for charge neutralization and hence bring about a B → Z transition in the same polymer. From the model building studies the mode of action of the cobalt—hexamine complex in stabilizing the Z-form is postulated.Keywords
This publication has 8 references indexed in Scilit:
- The Three-Dimensional Structure of DNAAnnual Review of Biochemistry, 1982
- Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomesNature, 1981
- Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).Proceedings of the National Academy of Sciences, 1981
- Left-Handed Double Helical DNA: Variations in the Backbone ConformationScience, 1981
- High-salt d(CpGpCpG), a left-handed Z′ DNA double helixNature, 1980
- Molecular structure of a left-handed double helical DNA fragment at atomic resolutionNature, 1979
- Polymorphism of a synthetic DNA in solutionNature, 1976
- Different conformations of double‐stranded nucleic acid in solution as revealed by circular dichroismBiopolymers, 1973