Abstract
The strength of antibody activities in mother's sera treated with 2-mercaptoethanol was graded “mercaptoethanol-stable antibody grade (MESA grade) I-IV”. This grading was applied to 108 mothers with ABO-incompatible infants or husbands. In general, cases with immunologically normal infants (severity grade I) corresponded with mercaptoethanol-stable antibody grade I and II; cases with heavily jaundiced infants (severity grade III) corresponded with mercaptoethanol-stable antibody grade III; cases with infants suffering from kernicterus or saved through exchange transfusion (severity grade IV) corresponded with mercaptoethanol-stable antibody grade IV. Two cases of successful antenatal prediction of ABO-hemolytic disease and a case of failed prediction were reported.

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