A Case of CD3 +, CD4−, CD8−, WT31−Acute T-Cell Leukemia
- 1 July 1989
- journal article
- case report
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 92 (1) , 115-119
- https://doi.org/10.1093/ajcp/92.1.115
Abstract
The article reports a case of acute T-cell leukemia (T-ALL) with the unusual CD3+, WT31− phenotype. On surface marker analysis, the blast cells were found to be CD7+, CD2−, CD5−, CD1−, CD4−, CD8−, CD3+ and negative for B-lymphoid and myeloid lineage. The cells had both TCRβ and TCRγ gene rearrangement but had negative results with the monoclonal antibody WT31, which reacts with a framework epitope on the Tα/β heterodimer (Ti) of the conventional T-cell receptor (TCR). This suggests an association of the CD3 molecular complex with a different polypeptide (the alternate TCRγ). In two similar reported cases of T-ALL (WT31−, CD3+, CD4−, CD8−), the CD3 molecular complex was found to be associated with a product of the Tγ gene.Keywords
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