ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA COLI UNDERGOING INDUCED β-GALACTOSIDASE SYNTHESIS
Open Access
- 1 November 1959
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 78 (5) , 613-623
- https://doi.org/10.1128/jb.78.5.613-623.1959
Abstract
When the metabolic Activity of a system under induction is essential to the formation of that system, the response of each cell in a population is sharply dependent upon whether it possesses a minimum unit of the induced activity. As a result, the formation of enzyme by the population is heterogenous. Both the formation and nonformation of enzyme is passed on clonally to the descendants. Two induced systems: the galactoside-permease and [beta]-galactosidase (Cohen and Monod, 1957) of E. coli and the galactozymase of long-term adapting yeast (Spiegelman, 1951) can be understood in terms of this concept for which experimental evidence is presented.Keywords
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