Distribution in tissue sections of the human groEL stress‐protein homologue
- 1 January 1990
- Vol. 98 (1-6) , 437-441
- https://doi.org/10.1111/j.1699-0463.1990.tb01055.x
Abstract
A monoclonal antibody (ML30) raised against the 65 kDa heat-shock protein of mycobacteria showed widespread staining of sections from standard paraffin-embedded human tissues. The staining had a granular pattern and was particularly marked in cells with abundant mitochondria. Increased staining was observed in the synovial lining, histocytes and in the endothelium of reactive and rheumatoid synovium; it was also increased in the reactive lung alveolar lining. It is suggested that the antibody identifies an epitope in mitochondria of a protein homologous with the groEL heat-shock protein of bacteria.Keywords
This publication has 17 references indexed in Scilit:
- Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondriaNature, 1989
- Raised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis.Annals of the Rheumatic Diseases, 1989
- Immunological study of the defined constituents of mycobacteriaSpringer Seminars in Immunopathology, 1988
- SYNOVIAL FLUID T CELL REACTIVITY AGAINST 65 kD HEAT SHOCK PROTEIN OF MYCOBACTERIA IN EARLY CHRONIC ARTHRITISThe Lancet, 1988
- A role for heat shock proteins in inflammation?Immunology Today, 1988
- Homologous plant and bacterial proteins chaperone oligomeric protein assemblyNature, 1988
- Antigenic relatedness of a strongly immunogenic 65 kDA mycobacterial protein antigen with a similarly sized ubiquitous bacterial common antigenMicrobial Pathogenesis, 1988
- Amino-Acid Sequence Homology of a Polymorphic Cellular Protein from Human Lymphocytes and the Chaperonins fromEscherichia coli (groEL)and Chloroplasts (Rubisco-Binding Protein)Biological Chemistry Hoppe-Seyler, 1988
- Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritisNature, 1988
- Modulators of the eukaryotic heat shock responseExperimental Cell Research, 1986