ISOLATION AND STRUCTURE OF ANOTHER β‐MELANOTROPIN FROM SALMON PITUITARY GLANDS

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Abstract
A heptadecapeptide has been isolated from a side fraction of β-MSH in an acid acetone extract of the pituitary of the salmon, Oncorhynchus keta. The sequence analysis revealed the peptide to be another form of salmon β-MSH with following primary structure; H-Asp-Gly-Ser-Tyr-Arg-Met-Gly-His-Phe-Arg-Trp-Gly-Ser-Pro-Thr-Ala-Ile-OH. The findings of two distinctive β-MSHs as well as two endorphins as reported previously in the pituitary extract suggest that the teleost pituitary may secrete two different precursor molecules, β-LPH, and thus also higher molecular weight precursors.