Breakdown and Reestablishment of Blood-Aqueous Barrier With Implant Surgery

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Abstract
• Preoperative and serial postoperative anterior chamber fluorophotometry was performed after oral administration of fluorescein sodium in patients undergoing extracapsular cataract extraction combined with intraocular lens implantation. In placebo-treated eyes, the blood-aqueous barrier was reestablished at three months after surgery. The administration of topical indomethacin before and after surgery markedly decreased aqueous fluorescein concentration, and the blood-aqueous barrier was reestablished within five weeks. Because all patients were given sub-Tenon's injection of steroids immediately after surgery and intensive topical steroid therapy postoperatively, the effect of topical indomethacin was additive to or synergistic with steroids. The addition of topical indomethacin caused a small but statistically significant increase in the postoperative intraocular pressure; this effect lasted nine weeks.

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