OCTOPAMINE: A HIGH‐AFFINITY UPTAKE MECHANISM IN THE NERVOUS SYSTEM OF THE COCKROACH
- 1 May 1978
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 30 (5) , 1015-1022
- https://doi.org/10.1111/j.1471-4159.1978.tb12394.x
Abstract
Abstract— In the CNS of the cockroach, Periplaneta americana, the uptake of the biogenic amine, octopamine, can be divided into three components. High and low affinity Na+‐sensitive components (Km's 0.5 μ and 19.8 UM respectively) are present, together with a Na+‐insensitive component which shows no saturation kinetics between 0.07 and 100 μ The structure‐specificity dependence of the components and their drug sensitivity have been examined. The significance of the high‐affinity uptake component is discussed in terms of amine inactivation, and its parallels with noradrenaline uptake in the vertebrate nervous system are considered.This publication has 30 references indexed in Scilit:
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