Impaired Bioavailability of Famotidine Given Concurrently with a Potent Antacid
- 1 July 1989
- journal article
- research article
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 29 (7) , 670-672
- https://doi.org/10.1002/j.1552-4604.1989.tb03399.x
Abstract
The effect of a high potency antacid on the oral bioavailability of a single dose of famotidine (40 mg) was evaluated in normal volunteers according to a randomized cross‐over design. Ingestion of the antacid concurrently with famotidine resulted in a significant reduction of peak plasma famotidine concentration (from 156 ± 22 to 104 ± 7, P < 0.05) and area under the famotidine plasma concentration curve (from 956 ± 125 to 607 ± 56, P < 0.02). No significant interaction was observed when the antacid was ingested 2 hours after famotidine administration.This publication has 6 references indexed in Scilit:
- Effects of antacids and food on absorption of famotidine.British Journal of Clinical Pharmacology, 1987
- Analytical method for the quantification of famotidine, an H2-receptor blocker, in plasma and urineJournal of Chromatography B: Biomedical Sciences and Applications, 1985
- High dose of antacid (Mylanta II) reduces bioavailability of ranitidine.BMJ, 1982
- Impaired cimetidine absorption due to antacids and metoclopramideEuropean Journal of Clinical Pharmacology, 1981
- Disposition of sodium valproate in epileptic patients.British Journal of Clinical Pharmacology, 1978