Solute Retention in Column Liquid Chromatography. III. Computer Optimization of Mobile-Phase Compositions: Program Window

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Abstract
A program is described that calculates solute retentions (thence optimized conditions for their separation) from data acquired solely from chromatographic measurements. A pre-sorting loop identifies the relevant (window-diagram boundary) pairs of solutes within a user-defined value of the most-difficult separation factor, Sf. The program run time is consequently shortened by several factors over previously-used “brute-force” techniques wherein all possible pairs are considered at each value of the independent parameter(s) to be optimized. The required CPU space reserved for arrays is thereby also diminished. The program was written for an APPLE II Plus system; statements not compatible with other versions of BASIC are pointed out and discussed.