CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice

Open Access
Publisher Website
Google Scholar
Abstract
DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (−/−) and CD8 (−/−) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.

This publication has 0 references indexed in Scilit: