THE TRANSFER OF [131I]‐LABELLED IMMUNOGLOBULINS AND SERUM ALBUMIN FROM BLOOD INTO MILK OF LACTATING EWES

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Abstract
Summary: Human serum albumin, 7S globulin, slow IgG and fast IgG were Labelled with [131I] iodine and injected intravenously into a total of 19 ewes. The mean (whey : serum) ratios for human serum albumin, 7S globulin (mainly fast IgG), slow IgG and fast IgG were respectively 0·044, 0·052, 0·025 and 0·062. There was a sharp increase in the (whey : serum) ratios for human serum albumin, and slow IgG compared with fast IgG as the glands became inflamed following the infusion of virulent staphylococci or α‐haemolysin into the test sinus. Thus 12hr. after infection the (whey : serum) ratio for slow IgG and human serum albumin had increased 250–500% above pre‐infection values while the ratio for fast IgG had increased by only 160%.Each under half became acutely inflamed within 4hr of the infusion of α‐haemolysin. At this time the (whey : serum)ratios for slow IgG were increased 317–640% above the pre‐infection values, whereas those for IgG were increased only 135–188%.There result suggest that a Selective mechanism of transfer for fast IgG into milk similar to that existing during colostrum formation continues into lactation and that acute inflammation inhibits this mechanism

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