Central nervous system toxicity of quinolones: human and animal findings
Open Access
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 26 (suppl B) , 219-225
- https://doi.org/10.1093/jac/26.suppl_b.219
Abstract
Quinolones have been reported to induce CNS reactions in 0.9–2.1% of cases, but severe reactions occur in less than 0.5%. Flumequine and fleroxacin, but not other quinolones, have produced convulsions in animals after systemic administration; by interventricular injection convulsions could be produced by some quinolones, but by pefloxacin only when a dose of 400 ng was reached. A possible mechanism for CNS excitation may be the displacement of GABA from receptors. Quinolones may interact with other drugs—theophylline, caffeine, non-steroidal anti-inflammatory drugs—in producing CNS effects.Keywords
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