Atypical fibroxanthoma of the skin.An ultrastructural study of two cases

Open Access
Publisher Website
Google Scholar
Abstract
The ultrastructure of two atypical fibroxanthomas of the skin was studied. The first lesion was a spindle cell tumor on light microscopy, which electron micros copy revealed was composed of undifferentiated mesenchymal cells. The second lesion had a highly pleomorphic appearance on both light and electron microscopy. It was formed by atypical histiocytic cells and abundant “typical” Langerhans cells. The second lesion was considered to be a proliferation either of atypical Langerhans cells or of histiocytes related to Langerhans cells. Thus, atypical fibroxanthoma of skin may not be a homogeneous entity but could be a group of mesenchymal proliferative lesions in a similar clinical setting.