Direct meso-alkylation of meso-formylporphyrins using Grignard reagents

1 January 1996

journal article
research article
Published by Royal Society of Chemistry (RSC) in Chemical Communications

No. 15,p. 1759-1760
https://doi.org/10.1039/cc9960001759

Abstract

Direct meso-alkylation of zinc(II) or metal-free 5-formyloctaethylporphyrin is achieved by use of Grignard reagents (such as MeMgBr, EtMgBr and PhCH₂MgCl); regioselective attack at the 15-position of the prophyrin macrocycle is observed and affords the unexpected 5-formyl-15-alkylporphyrins by way of a phlorin intermediate.

Keywords

DIRECT MESO
MESO ALKYLATION
REGIOSELECTIVE ATTACK
PHLORIN INTERMEDIATE
REAGENTS DIRECT
USING GRIGNARD
METAL FREE

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