Abnormal cobalamin metabolism in a case of juvenile pernicious anaemia with neurological symptoms

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Abstract
Studies of cobalamin metabolism in case of juvenile pernicious anaemia during haematological remission showed that while plasma cobalamins were normal there was some depletion of erythrocyte cobalamins. In addition, the plasma distribution of apo‐ and holo‐transcobalamins was markedly abnormal, holo‐TCII being increased, yet the patient's plasma promoted less cellular synthesis of adenosylcobalamin by cultured lymphocytes than did plasma from a control subject. The results suggest that holo‐TCII may in this case have been ineffective and provide further evidence for the importance of TCII in intracellular synthesis of adenosylcobalamin.