Genotoxic Effects of Aristolochic Acid in the Mouse Micronucleus Test

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Abstract
Aristolochic acid was screened in the micronucleus test for genotoxic effects on bone marrow cells. Male and female mice were each given a single intravenous injection of 6, 20, or 60 mg/kg. There was also a negative control group given distilled water and a positive control group receiving cyclophosphamide. Within 48 hours of administration, the males treated with 6 mg/kg or over and the females given 20 mg/kg or over showed increases in the numbers of micronucleated polychromatic erythrocytes that represented statistically significant differences from the negative control.