NDR kinases regulate essential cell processes from yeast to humans
Top Cited Papers
- 1 April 2006
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 7 (4) , 253-264
- https://doi.org/10.1038/nrm1891
Abstract
Members of the NDR (nuclear Dbf2-related) protein-kinase family are essential components of pathways that control important cellular processes, such as morphological changes, mitotic exit, cytokinesis, cell proliferation and apoptosis. Recent progress has shed light on the mechanisms that underlie the regulation and function of the NDR family members. Combined data from yeast, worms, flies, mice and human cells now highlight the conserved and important roles of the different NDR kinases in distinct cellular processes.Keywords
This publication has 132 references indexed in Scilit:
- The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAPCell, 2005
- Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, MatsCell, 2005
- The Salvador partner Hippo promotes apoptosis and cell-cycle exit in DrosophilaNature Cell Biology, 2003
- Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathwayNature Cell Biology, 2003
- The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes ApoptosisCell, 2003
- hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and wartsCell, 2003
- New genes involved in cancer identified by retroviral taggingNature Genetics, 2002
- salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell LinesCell, 2002
- Yeast Cbk1 and Mob2 Activate Daughter-Specific Genetic Programs to Induce Asymmetric Cell FatesCell, 2001
- Systematic variation in gene expression patterns in human cancer cell linesNature Genetics, 2000